Programme 3
AI-Enabled Causal Inference for Disease Control
This programme aims to develop new methodology for predicting seasonal influenza epidemics around the world, by using global surveillance data and electronic medical records from Hong Kong’s Hospital Authority and elsewhere. Models will be developed to provide reliable predictions of future influenza activity and explore the impact of public health interventions such as travel restrictions and school closures. Moreover, the research team will sequence the genomes of bacteria identified in samples collected from patients and compare the genetic characteristics of these bacteria with their drug resistance profiles. New genes will be identified that determine drug resistance, as well as determine the background factors that influence the appearance of these genes.
This programme will also improve the surveillance and diagnosis of respiratory virus infections in mainland China by using a large dataset of laboratory diagnoses of respiratory pathogens and creating a surveillance dashboard that will provide timely reports of the pathogens circulating in different regions of China. This information will aid clinical diagnosis and management.
Scientific Leadership
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Professor Benjamin Cowling
Lead Scientist
Professor Benjamin Cowling
Lead Scientist (Programme 3)
Laboratory of Data Discovery for HealthProfessor Cowling is the Professor and Head of the Division of Epidemiology and Biostatistics, School of Public Health at the University of Hong Kong (HKU). He currently leads the programme “AI-Enabled Causal Inference for Disease Control” (Programme 3) at the Laboratory of Data Discovery for Health.
He is responsible for teaching the introductory module in epidemiology on the Master of Public Health curriculum, and is the chairman of the Departmental Research Postgraduate Committee at HKU School of Public Health. He is a co-director of the WHO Collaborating Centre for Infectious Disease Epidemiology and Control at the School.
His primary research focus is in infectious disease epidemiology, and his latest research has focused on the modes of respiratory virus transmission, influenza vaccination effectiveness, and immunity to infections at the individual and population level. He has strong links with China CDC, and the NIGMS-funded Harvard Center for Communicable Disease Dynamics.
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Dr Eric Lau
Co-Principal Investigator
Scientific Officer, Division of Epidemiology and Biostatistics, School of Public Health, The University of Hong KongDr Eric Lau
Co-Principal Investigator (Programme 3)
Scientific Officer, Division of Epidemiology and Biostatistics, School of Public Health, The University of Hong KongDr Lau is the Co-Principal Investigator of the programme “AI-Enabled Causal Inference for Disease Control” (Programme 3) at the Laboratory of Data Discovery for Health.
He is a Scientific Officer in the Division of Epidemiology and Biostatistics, School of Public Health at the University of Hong Kong. He is actively involved in teaching and is the coordinator of two Advanced Statistics courses in the Master of Public Health programme of the School.
He is an infectious disease epidemiologist with a focus on surveillance and transmission dynamics of infectious diseases in human and animals, and assessment of infection control measures. His previous work has contributed to the understanding and control of emerging human and zoonotic diseases such as SARS, MERS, scarlet fever, avian influenza A(H7N9) and COVID-19. His latest projects focus on transmission dynamics of COVID-19 and other emerging and re-emerging diseases, and surveillance strategy of respiratory diseases in human and avian influenza in live poultry markets.
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Professor Gabriel M. Leung
Co-Principal Investigator
Professor Gabriel M. Leung
Managing Director and Chief Scientific Officer
Laboratory of Data Discovery for HealthOne of Asia’s most respected higher education and health leaders, Professor Leung is known for his commitment to expanding student opportunity, building strong institutions and nurturing impactful innovation. He is the fortieth Dean of Medicine and inaugural Helen and Francis Zimmern Professor in Population Health at the University of Hong Kong, and currently directs the Laboratory of Data Discovery for Health.
His career has straddled academe and public service. Formerly, he was Head of Community Medicine at the University as well as Hong Kong’s first Under Secretary for Food and Health and fifth Director of the Chief Executive’s Office in government.
A specialist in public health medicine by training, Professor Leung is one of the region’s leading epidemiologists and global health exponents. His work has revolved around topics that have major population health impact locally, where Hong Kong is a reliable and unique epidemiologic sentinel for mainland China and the Chinese diaspora, or where it is best placed to address the fundamental science at hand globally.
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Dr Peng Wu
Co-Principal Investigator
Assistant Professor, Division of Epidemiology and Biostatistics, School of Public Health, The University of Hong KongDr Peng Wu
Co-Principal Investigator (Programme 3)
Assistant Professor, Division of Epidemiology and Biostatistics, School of Public Health, The University of Hong KongDr Wu is the Co-Principal Investigator of the programme “AI-Enabled Causal Inference for Disease Control” (Programme 3) at the Laboratory of Data Discovery for Health.
She is an Assistant Professor in the Division of Epidemiology and Biostatistics, School of Public Health at the University of Hong Kong. She is responsible for an introductory module in infectious diseases in the MPH curriculum.
Her primary research area is infectious disease epidemiology. She has a growing interest in the epidemiology of antimicrobial resistance, as well as a continued interest in influenza (seasonal and avian influenza), RSV, hand, foot and mouth disease and other emerging respiratory infections. Her research involves investigation of the burden and transmission dynamics of infectious diseases, and using knowledge of underlying mechanisms to optimize the use of control measures.
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Other Project Members
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Dr Sheikh Taslim Ali
Assistant Professor
Dr Sheikh Taslim Ali
Assistant Professor (Programme 3)
Laboratory of Data Discovery for HealthDr Ali is a Co-Investigator of the programme “AI-Enabled Causal Inference for Disease Control” (Programme 3) at the Laboratory of Data Discovery for Health.
He is a Assistant Professor in the Division of Epidemiology and Biostatistics, School of Public Health at the University of Hong Kong. He is the course coordinator of Introduction to Biostatistics, one of the core courses for the Master of Public Health programme of the School.
Dr Ali’s research interests are mathematical and statistical epidemiology, modelling of infectious diseases and optimization of control policies. The main focus of his current research is to understand the disease dynamics (including influenza, COVID-19, RSV, hand-foot-and-mouth disease and other respiratory diseases) under the effect of time-varying interventions and seasonal forces (e.g. meteorological, pollutants and socio-economic). He develops the general prediction and forecast models for disease outbreaks, with the aim of determining how the effectiveness of containment and mitigation policies depends on disease severity.
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Dr Zhanwei Du
Research Assistant Professor
Dr Zhanwei Du
Research Assistant Professor (Programme 3)
Laboratory of Data Discovery for HealthDr Du is a Co-Investigator of the programme “AI-Enabled Causal Inference for Disease Control” (Programme 3) at the Laboratory of Data Discovery for Health.
He is a Research Assistant Professor in the Division of Epidemiology and Biostatistics, School of Public Health at the University of Hong Kong. His general research area is computational epidemiology, machine learning and data science. He mainly focuses on modeling complex phenomena in biological and social systems. The applications include computational social science with an emphasis on smart city and computational biology covering a wide range of communicable and non-communicable diseases (e.g., COVID-19, influenza, Ebola, sexual transmission.
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Featured Publications
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Nowcasting towards sustainable SARS-CoV-2 endemicity
- The Lancet27 Oct 2021
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- The Lancet Regional Health – Western Pacific
13 Aug 2021
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COVID-19 transmission in Hong Kong despite universal masking
- Journal of Infection31 Jul 2021
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Assessing Community Vulnerability over 3 Waves of COVID-19 Pandemic, Hong Kong, China
- Emerging Infectious Diseases27 Jul 2021
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Comparative immunogenicity of mRNA and inactivated vaccines against COVID-19
- The Lancet Microbe16 Jul 2021
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- Clinical Infectious Diseases
15 Jul 2021
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Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality
- Nature Medicine05 Jul 2021
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- Clinical Infectious Diseases
12 Jun 2021
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- The Journal of Infectious Diseases
04 Jun 2021
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Risk for International Importations of Variant SARS-CoV-2 Originating in the United Kingdom
- Emerging Infectious Diseases27 May 2021
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Transmission dynamics and control of two epidemic waves of SARS-CoV-2 in South Korea
- BMC Infectious Diseases26 May 2021
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Serial intervals and case isolation delays for COVID-19: a systematic review and meta-analysis
- Clinical Infectious Diseases26 May 2021
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- Emerging Infectious Diseases
01 May 2021
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- The Journal of Infectious Diseases
15 Apr 2021
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Assessing asymptomatic, pre-symptomatic and symptomatic transmission risk of SARS-CoV-2
- Clinical Infectious Diseases27 Mar 2021
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- EClinicalMedicine
13 Feb 2021
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- Clinical Infectious Diseases
06 Jan 2021
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Face masks and COVID-19: don't let perfect be the enemy of good
- Euro-surveillance10 Dec 2020